反应详情

A mixture of 7-chloro-2-(2,4-diformylphenoxymethyl)-quinoline (5.7 g) and pyridine hydrochloride (11.4 g) in toluene (140 ml) was stirred under reflux for 2 hours. After being cooled, the appeared crystals were collected, washed with toluene and water. The resulting crystals were washed with ethanol (100 ml) and dried to give 7-chloro-2-(5-formylbenzofuran-2-yl)quinoline (4.67 g).

1. temperatureunder reflux for 2 hours
2. temperatureAfter being cooled
3. customthe appeared crystals were collected
4. washwashed with toluene and water
5. washThe resulting crystals were washed with ethanol (100 ml)
6. customdried