HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridinium chloride → 7-Chloro-2-(5-formylbenzofuran-2-yl)quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridinium chloride | HCID 10176127 | — |
| Reactant | 7-Chloro-2-(2,4-diformylphenoxymethyl)-quinoline | HCID 22922167 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 7-Chloro-2-(5-formylbenzofuran-2-yl)quinoline | HCID 22922145 | 86.7% |
Reaction Steps
A mixture of 7-chloro-2-(2,4-diformylphenoxymethyl)-quinoline (5.7 g) and pyridine hydrochloride (11.4 g) in toluene (140 ml) was stirred under reflux for 2 hours. After being cooled, the appeared crystals were collected, washed with toluene and water. The resulting crystals were washed with ethanol (100 ml) and dried to give 7-chloro-2-(5-formylbenzofuran-2-yl)quinoline (4.67 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05661159 |
| Source dataset | uspto-grants-1997_08 |
| ORD ID | ord-86d6034f63b34dd990601a7fa48b1036 |
| Source note | uspto-grants-1997_08 |