Hydrochloric Acid → HCID 22922296, compound

HRID 2258531Notes

Reaction equation

HRID 2258531 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C:11]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)([CH2:14][S:15]([CH2:18][C:19]2[CH:24]=[C:23]([C:25]([F:28])([F:27])[F:26])[CH:22]=[C:21]([C:29]([F:32])([F:31])[F:30])[CH:20]=2)(=[O:17])=[O:16])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:39]>C(OCC)C>[ClH:39].[C:33]1([C:11]2([CH2:14][S:15]([CH2:18][C:19]3[CH:20]=[C:21]([C:29]([F:30])([F:31])[F:32])[CH:22]=[C:23]([C:25]([F:27])([F:28])[F:26])[CH:24]=3)(=[O:16])=[O:17])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 229223061t-Butoxycarbonyl-4-phenyl-4-[3,5-bis(trifluoromethyl) benzylsulphonyl methyl]piperidine

Product 1

HCID 22922296HCID 22922296, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

1t-Butoxycarbonyl-4-phenyl-4-[3,5-bis(trifluoromethyl) benzylsulphonyl methyl]piperidine was dissolved in diethyl ether (5 ml) and ethereal HCl (5 ml) was added. The solution was left standing for 16 h, solvent was removed and residue was recrystallised from isopropyl alcohol/isopropyl ether giving 4-phenyl-4-[3,5-bis(trifluoromethyl)benzylsulphonylmethyl]piperidine hydrochloride (196 mg) as a white solid, m.p. 249° C. (dec), m/z (CI+) 466 (M+ +1). Found: C, 49.90; H, 4.36; N, 2.89. C21H21NO2SF6. HCl requires C, 50.25; H, 4.42; N, 2.79.

Workup

  1. waitThe solution was left
  2. customsolvent was removed
  3. customresidue was recrystallised from isopropyl alcohol/isopropyl ether

Sources & evidence

ORD record
ord-f4d89640f767487e9b8e2bea424cabba
Source dataset
uspto-grants-1997_08
Patent number
US05661162

Reaction notes

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