Phosphorus tribromide → 1-(Bromomethyl)-2,4-dimethoxybenzene
Reaction equation
O[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[O:11][CH3:12].P(Br)(Br)[Br:14]>CCOCC>[Br:14][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[O:11][CH3:12]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 0.537 g of 1-hydroxymethyl-2,4-dimethoxybenzene in 5 ml of ether is cooled to -10° C., under a nitrogen atmosphere, and a solution of 0.1 ml of phosphorus tribromide in 2 ml of ether is added dropwise. The 1-bromomethyl-2,4-dimethoxybenzene thus obtained is stored in solution at -30° C.
Sources & evidence
- ORD record
- ord-11cd3f241c7b471c9b9999aabac0fdb2
- Source dataset
- uspto-grants-1997_08
- Patent number
- US05661169
Reaction notes
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