Hydrogen Bromide → 5-Bromo-3-(bromomethyl)pyridin-2-amine hydrobromide

HRID 225858노트

반응식

HRID 225858 반응식
[NH2:1][C:2]1[C:7]([CH2:8]O)=[CH:6][C:5]([Br:10])=[CH:4][N:3]=1.[BrH:11]>>[BrH:10].[NH2:1][C:2]1[C:7]([CH2:8][Br:11])=[CH:6][C:5]([Br:10])=[CH:4][N:3]=1

참가 물질

3

반응물 2

HCID 260Hydrogen BromideHCID 108913662-Amino-5-bromo-3-(hydroxymethyl)pyridine

생성물 1

HCID 534200525-Bromo-3-(bromomethyl)pyridin-2-amine hydrobromide

실험 절차

A solution of 2-amino-5-bromo-3-hydroxymethylpyridine (5.00 g, 24.6 mmole), from Preparation 14(b), in 48% aqueous HBr (50 mL), was heated at reflux for 12 hrs. The reaction was concentrated and toluene was used to azeotrope the residual H2O. The resulting light brown solid was placed under high vacuum overnight and used directly.

후처리

  1. temperatureat reflux for 12 hrs
  2. concentrationThe reaction was concentrated
  3. customwas placed under high vacuum overnight

출처 및 근거

ORD 기록
ord-f8c7ddbf282841c394e8cece08b2cfc9
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07557125B2

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