Aluminium lithium hydride → HCID 22907247, compound

HRID 2258586Notes

Reaction equation

HRID 2258586 reaction equation
[H-].[H-].[H-].[H-].[Li+].[Al+3].[N:7]1([CH:16]2[CH2:21][CH2:20][O:19][C:17]2=[O:18])[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:9]=[CH:8]1>C1COCC1>[N:7]1([CH:16]([CH2:21][CH2:20][OH:19])[CH2:17][OH:18])[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:9]=[CH:8]1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 22907241HCID 22907241, compound

Product 1

HCID 22907247HCID 22907247, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To an ice cooled suspension of LAH (0.84 g, 0.022 mol) in dry THF (60 mL) was added 2-(indol-1-yl)butyrolactone (4 g, 0.02 mol). After 1 hour the mixture was quenched successively with water (0.84 mL), 15% aqueous sodium hydroxide (0.84 mL), and water (2.5 mL). The reaction was filtered and the filtrate was dried, and evaporated. The material obtained, 2.5 g of colorless oil (61% of theory), was used directly in the next reaction.

Workup

  1. customAfter 1 hour the mixture was quenched successively with water (0.84 mL), 15% aqueous sodium hydroxide (0.84 mL), and water (2.5 mL)
  2. filtrationThe reaction was filtered
  3. customthe filtrate was dried
  4. customevaporated
  5. customThe material obtained

Sources & evidence

ORD record
ord-a7671d011062497b9ef1e95cc9643211
Source dataset
uspto-grants-1997_08
Patent number
US05661173

Reaction notes

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