6-Bromoquinoline → HCID 178422846, 화합물

HRID 2258851노트

반응식

HRID 2258851 반응식
Brc1ccc2ncccc2c1.Cc1ccc2c(cnn2C2CCCCO2)c1B(O)O>CC(=O)[O-].CC(=O)[O-].CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.CO.[Cs+].[F-].[Pd+2]>Cc1ccc2c(cnn2C2CCCCO2)c1.Cc1ccc2c(cnn2C2CCCCO2)c1-c1ccc2ncccc2c1.c1ccc2ncccc2c1.c1cnc2ccc(-c3ccc4ncccc4c3)cc2c1

참가 물질

12

반응물 2

HCID 792436-BromoquinolineHCID 129009568[5-Methyl-1-(oxan-2-yl)-1H-indazol-4-yl]boronic acid

생성물 6

HCID 7047Quinoline수율 4.453%HCID 792436-Bromoquinoline수율 21.475%HCID 6207116,6'-Biquinoline수율 6.049%HCID 10751213HCID 10751213, 화합물수율 2.02%HCID 129009568[5-Methyl-1-(oxan-2-yl)-1H-indazol-4-yl]boronic acid수율 5.513%HCID 178422846HCID 178422846, 화합물수율 60.21%

시약·촉매·용매 4

HCID 25953Cesium fluoride시약HCID 167845palladium(II) acetate촉매HCID 111557942-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenyl촉매HCID 887Methanol용매

반응 조건

온도
100 °C

출처 및 근거

ORD 기록
ord-f9625eb54cbc4cf1b3fe0cf953f0398f
출처 데이터셋
HTE Suzuki coupling dataset

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