Methyl iodide → 6-Methoxy-2-methylbenzo[b]thiophene

HRID 2259210Notes

Reaction equation

HRID 2259210 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[CH:10]=[CH:9][S:8][C:7]=2[CH:11]=1.[CH3:12]I>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[CH:10]=[C:9]([CH3:12])[S:8][C:7]=2[CH:11]=1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 136342376-Methoxy-1-benzothiophene

Product 1

HCID 221434866-Methoxy-2-methylbenzo[b]thiopheneYield 64.5%

Procedure

The same operations as in Preparation example 1 were carried out using 180 mg of 6-methoxybenzo[b]thiophene, and 450 mg of methyl iodide in place of cyclohexanone, and then purification was carried out by TLC (developing solvent, chloroform:n-hexane=1:19) to obtain 126 mg of 6-methoxy-2-methylbenzo[b]thiophene.

Workup

  1. customThe same operations as in Preparation example 1
  2. custompurification

Sources & evidence

ORD record
ord-c6041b427f3842f89710d39091a12f47
Source dataset
uspto-grants-1995_12
Patent number
US05472962

Reaction notes

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