2-(Chloromethyl)anisole → HCID 19003118, compound

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Reaction Steps

Following the method of Example 1, 2-methoxybenzyl chloride (3.9) and N α BOC-L-tryptophan (7.6 g) gave the title compound which was recrystallised from ethyl acetate/petroleum ether (3.4 g), m.p. 132°-133° C. 1H NMR (360 MHz, CDCl3) δ7.99 (1H, s), 7.56 (1H, d, J=Hz), 7.33-7.07 (5H, m), 6.93-6.66 (3H, m), 5.21-5.07 (3H, m), 4.70-4.67 (1H, m), 3.01 (3H, s), 3.30 (1H, m), 1.41 (9H, s). Found: C, 67.91; H, 6.65; N, 6.60; C24H28N2O5 requires C, 68.00; H, 6.70; N, 6.66%.

Provenance & Evidence