反应详情

L Tryptophan (10.2 g) was cautiously added in portions to a stirred solution of lithium aluminium hydride in tetrahydrofuran (1M, 150 ml). The reaction was stirred for 72 hours and then heated to reflux for 1 hour. The reaction mixture was cooled and then quenched carefully with 2N sodium hydroxide (150 ml). Ethyl acetate (500 ml) was added and the mixture was filtered through a pad of Celite. The organic phase was washed with water, dried (MgSO4) and evaporated to yield the crude title compound.

1. temperatureheated
2. temperatureto reflux for 1 hour
3. temperatureThe reaction mixture was cooled
4. customquenched carefully with 2N sodium hydroxide (150 ml)
5. additionEthyl acetate (500 ml) was added
6. filtrationthe mixture was filtered through a pad of Celite
7. washThe organic phase was washed with water
8. dry with materialdried (MgSO4)
9. customevaporated