HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Buspirone Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Buspirone | HCID 2477 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Buspirone Hydrochloride | HCID 36431 | — |
Reaction Steps
treating the 8-[4-[4-(pyrimidine-2-yl)-piperazine-1-yl]-butyl]-8-aza-spiro[4.5]decane-7,9-dione base with hydrogen chloride in ethyl acetate or isopropanol at a temperature not exceeding 70° C. under stirring and isolating the 8-[4-[4-(pyrimidine-2-yl)-piperazine-1-yl]-butyl]-8-aza-spiro[4.5]decane-7,9-dione hydrochloride melting at 201°-203° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05473072 |
| Source dataset | uspto-grants-1995_12 |
| ORD ID | ord-b0ec1fd5f74f4f41be08fae594849ad9 |
| Source note | uspto-grants-1995_12 |