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HRID2259411

反应详情

EQUATION

反应方程式

HRID 2259411 的结构方程式

REACTANTS

反应物

2
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(c2ncccn2)CC1
HCID2477

Buspirone

C21H31N5O2

PRODUCTS

生成物

1
结构：Cl.O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(c2ncccn2)CC1
HCID36431

Buspirone hydrochloride

C21H32ClN5O2

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CC(C)O
溶剂HCID3776

Isopropanol

C3H8O

结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

treating the 8-[4-[4-(pyrimidine-2-yl)-piperazine-1-yl]-butyl]-8-aza-spiro[4.5]decane-7,9-dione base with hydrogen chloride in ethyl acetate or isopropanol at a temperature not exceeding 70° C. under stirring and isolating the 8-[4-[4-(pyrimidine-2-yl)-piperazine-1-yl]-butyl]-8-aza-spiro[4.5]decane-7,9-dione hydrochloride melting at 201°-203° C.

WORKUP

后处理

  1. customexceeding 70° C.