反应详情

To a stirred solution of 1-methyl-2-(methylaminomethyl)-1H-indole (1.5 g, 8.6 mmole) and Et3N (1.35 mL, 9.6 mmole) in CH2Cl2 (75 mL) at 0° C. was added dropwise acryloyl chloride (0.77 mL, 9.5 mmole) over 5 minutes. After 2 h the reaction was washed with cold H2O, brine, dried (MgSO4) and concentrated under vacuum. The residue was used without further purification.

1. washAfter 2 h the reaction was washed with cold H2O, brine
2. dry with materialdried (MgSO4)
3. concentrationconcentrated under vacuum
4. customThe residue was used without further purification