Hydrogen Peroxide → Acetophenone

HRID 2259462Notes

Reaction equation

HRID 2259462 reaction equation
[Br-].[Na+].[CH2:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH3:4].[OH:11]O>O.O.O.O.C([O-])(=O)C.[Co+2].C([O-])(=O)C>[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)(=[O:11])[CH3:4]

Participants

5

Reactant 3

HCID 784Hydrogen PeroxideHCID 7500Ethylbenzene2×HCID 253881Sodium Bromide

Product 1

HCID 7410AcetophenoneYield 91.1%

Reagents, catalysts & solvents 1

HCID 61372Cobalt(II) acetate tetrahydrateCatalyst

Procedure

The procedure of Example I was repeated, but this time cobalt (II) acetate tetrahydrate (0.003 moles), sodium bromide (0.005 moles), ethylbenzene (0.027 moles) and hydrogen peroxide (35%, 0.22 moles) were used. The final reaction mixture, analysed by HPLC, revealed that 97.0% of the ethylbenzene had been consumed, yielding products including acetophenone (91.1% yield).

Workup

  1. customThe final reaction mixture
  2. customhad been consumed
  3. customyielding products

Sources & evidence

ORD record
ord-f97ebd809c7d4117a671f80ab1c19752
Source dataset
uspto-grants-1995_12
Patent number
US05473101

Reaction notes

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