Trifluoroacetic acid → HCID 11315834, compound

HRID 225949Notes

Reaction equation

HRID 225949 reaction equation
[CH3:1][C:2]1([C:13]([NH:15][C@H:16]([C:25](=[O:34])[CH2:26][O:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH2:17][C:18]([O:20]C(C)(C)C)=[O:19])=[O:14])[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[CH2:3]1.FC(F)(F)C(O)=O>ClCCl>[CH3:1][C:2]1([C:13]([NH:15][C@H:16]([C:25](=[O:34])[CH2:26][O:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH2:17][C:18]([OH:20])=[O:19])=[O:14])[O:6][N:5]=[C:4]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:3]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86608352HCID 86608352, compound

Product 1

HCID 11315834HCID 11315834, compoundYield 99.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The compound prepared in Example 3 (530 mg, 1.136 mmol) was dissolved in dichloromethane (6 ml), and trifluoroacetic acid (3 ml) was added at 0□. The mixture was stirred for two hours while it was slowly warmed to room temperature, and concentrated under reduced pressure to give the title compound (Ibb) (465 mg) with a stoichiometric yield.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-936eb62a6c68435c8a07a7635f45b8e5
Source dataset
uspto-grants-2009_07
Patent number
US07557133B2

Reaction notes

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