Sodium Hydroxide → 2-methylthiazolo[5,4-b]pyridine N-oxide

HRID 2259521Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2259521
[CH3:1][C:2]1[S:3][C:4]2[C:9]([N:10]=1)=[CH:8][CH:7]=[CH:6][N:5]=2.ClC1C=CC=C(C(OO)=[O:19])C=1.[OH-].[Na+]>C(Cl)Cl>[CH3:1][C:2]1[S:3][C:4]2[C:9]([N+:10]=1[O-:19])=[CH:8][CH:7]=[CH:6][N:5]=2

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 70297m-Chloroperbenzoic acidHCID 6407272-Methylthiazolo[5,4-b]pyridine

Produkt 1

HCID 678064122-methylthiazolo[5,4-b]pyridine N-oxide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of the product of Step 2 (8.00 g) in 400 mL of CH2Cl2 was added m-chloroperbenzoic acid (26.0 g) and the mixture was stirred at room temperature overnight. NaOH 0.5M was added and the product was extracted in CH2Cl2 (6×), dried over Na2SO4, and purified by flash chromatography on silica with acetone: toluene 70:30 and acetone: toluene: methanol 40:40:20.

Aufarbeitung

  1. extractionthe product was extracted in CH2Cl2 (6×)
  2. dry with materialdried over Na2SO4
  3. custompurified by flash chromatography on silica with acetone: toluene 70:30 and acetone: toluene: methanol 40:40:20

Quellen und Nachweise

ORD-Eintrag
ord-f84899bed3a14723b2a584bddbc90dbb
Quelldatensatz
uspto-grants-1995_12
Patentnummer
US05472964

Notizen zur Reaktion

Wird geladen…