HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Sodium Hydroxide → 2-methylthiazolo[5,4-b]pyridine N-oxide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Sodium Hydroxide | HCID 14798 | — |
| Edukt | m-Chloroperbenzoic acid | HCID 70297 | — |
| Edukt | 2-Methylthiazolo[5,4-b]pyridine | HCID 640727 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | 2-methylthiazolo[5,4-b]pyridine N-oxide | HCID 67806412 | — |
Reaktionsschritte
To a solution of the product of Step 2 (8.00 g) in 400 mL of CH2Cl2 was added m-chloroperbenzoic acid (26.0 g) and the mixture was stirred at room temperature overnight. NaOH 0.5M was added and the product was extracted in CH2Cl2 (6×), dried over Na2SO4, and purified by flash chromatography on silica with acetone: toluene 70:30 and acetone: toluene: methanol 40:40:20.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05472964 |
| Quelldatensatz | uspto-grants-1995_12 |
| ORD ID | ord-f84899bed3a14723b2a584bddbc90dbb |
| Quellennotiz | uspto-grants-1995_12 |