反应详情

温度

0 °C

To a suspension of the product of Step 5 (3.733 g, 21 mmol) in 200 mL of EtOH at 0° C. was added NaBH4 (800 mg, 21 mmol) and the mixture was stirred at 0° C. for 5 min. Saturated aq. NH4Cl was then added slowly and the product was extracted in EtOAc:THF 1:1, dried over Na2SO4, and purified by flash chromatography on silica with acetone: toluene 30:70; yield: 3.49 g, (92%).

1. extractionthe product was extracted in EtOAc:THF 1:1
2. dry with materialdried over Na2SO4
3. custompurified by flash chromatography on silica with acetone: toluene 30:70