HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2259524Generated: November 1, 2026
Ammonium Chloride → 2-methylThiazolo[5,4-b]pyridine-5-methanol
https://huagongshe.com/reaction/2259524
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 5-Formyl-2-methylthiazolo[5,4-b]pyridine | HCID 19002916 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-methylThiazolo[5,4-b]pyridine-5-methanol | HCID 19002884 | — |
Reaction Steps
To a suspension of the product of Step 5 (3.733 g, 21 mmol) in 200 mL of EtOH at 0° C. was added NaBH4 (800 mg, 21 mmol) and the mixture was stirred at 0° C. for 5 min. Saturated aq. NH4Cl was then added slowly and the product was extracted in EtOAc:THF 1:1, dried over Na2SO4, and purified by flash chromatography on silica with acetone: toluene 30:70; yield: 3.49 g, (92%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05472964 |
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| Source dataset | uspto-grants-1995_12 |
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| ORD ID | ord-679ce88d777444b9b7297603e5f321c8 |
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| Source note | uspto-grants-1995_12 |
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