Methanesulfonic Acid → HCID 19001422, compound

HRID 2259563Notes

Reaction equation

HRID 2259563 reaction equation
[CH2:1]([N:4]1[N:8]=[N:7][C:6]([C:9]2[C:14](=[O:15])[N:13]3[CH:16]=[CH:17][CH:18]=[C:19]([CH3:20])[C:12]3=[N:11][CH:10]=2)=[N:5]1)[CH2:2][CH3:3].[CH3:21][S:22]([OH:25])(=[O:24])=[O:23]>C(O)C>[CH3:21][S:22]([OH:25])(=[O:24])=[O:23].[CH2:1]([N:4]1[N:8]=[N:7][C:6]([C:9]2[C:14](=[O:15])[N:13]3[CH:16]=[CH:17][CH:18]=[C:19]([CH3:20])[C:12]3=[N:11][CH:10]=2)=[N:5]1)[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 19001423HCID 19001423, compound

Product 1

HCID 19001422HCID 19001422, compoundYield 87.84%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.5 g (0.0055 moles) of 3-(2-propyl-2H-tetrazol-5-yl)-9-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine was dissolved in 20 ml of abs. ethanol under heating and stirring at reflux temperature. To the solution 0.6 ml (0.009 moles) of methanesulfonic acid was added dropwise. After a few minutes of stirring the reaction mixture was filtered and the filtrate was cooled down. The precipitating crystals were collected. 1.77 g (87.84%) of the title compound were obtained in the form of white crystals, m.p.: 154°-155° C.

Workup

  1. temperatureat reflux temperature
  2. stirringAfter a few minutes of stirring the reaction mixture
  3. filtrationwas filtered
  4. temperaturethe filtrate was cooled down
  5. customThe precipitating crystals were collected

Sources & evidence

ORD record
ord-66fef6f70a6b4cda818ed11b1e386bb1
Source dataset
uspto-grants-1995_12
Patent number
US05475000

Reaction notes

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