HCID 19001468, compound → HCID 19001482, compound

HRID 2259590Notes

Reaction equation

HRID 2259590 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH:12][C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[C:15]([Cl:20])[CH:14]=3)=[N:7][CH:8]=[N:9]2)=[CH:4][C:3]=1[N+:21]([O-])=O>C(O)(=O)C.[Fe]>[NH2:21][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:2]=1[Cl:1])[N:9]=[CH:8][N:7]=[C:6]2[NH:12][C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[C:15]([Cl:20])[CH:14]=1

Participants

4

Reactant 1

HCID 19001468HCID 19001468, compound

Product 1

HCID 19001482HCID 19001482, compoundYield 20%

Reagents, catalysts & solvents 2

HCID 23925IronCatalystHCID 176Acetic AcidSolvent

Procedure

Using an analogous procedure to that described in Example 9, 7-chloro-4-(3',4'-dichloroanilino)-6-nitroquinazoline was reduced with iron in acetic acid to give 6-amino-7-chloro-4-(3',4'-dichloroanilino)quinazoline in 20% yield;

Sources & evidence

ORD record
ord-f730c2ac00454b4dafde357f8bed9f2e
Source dataset
uspto-grants-1995_12
Patent number
US05475001

Reaction notes

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