4-Chlorobutyryl chloride → HCID 19001459, compound

Participants

Reaction Steps

Using an analogous procedure to that described in Example 5, 6-amino-4-(3'-chloro-4'-fluoroanilino)-7-fluoroquinazoline was reacted with 4-chlorobutyryl chloride to give 6-(4-chlorobutyramido)-4-(3'-chloro-4'-fluoroanilino)-7-fluoroquinazoline hydrochloride as a solid in 91% yield;

Provenance & Evidence