4-Chlorobutyryl chloride → HCID 19001459, compound

HRID 2259593Notes

Reaction equation

HRID 2259593 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[F:12])[N:8]=[CH:7][N:6]=[C:5]2[NH:13][C:14]1[CH:19]=[CH:18][C:17]([F:20])=[C:16]([Cl:21])[CH:15]=1.[Cl:22][CH2:23][CH2:24][CH2:25][C:26](Cl)=[O:27]>>[ClH:21].[Cl:22][CH2:23][CH2:24][CH2:25][C:26]([NH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[F:12])[N:8]=[CH:7][N:6]=[C:5]2[NH:13][C:14]1[CH:19]=[CH:18][C:17]([F:20])=[C:16]([Cl:21])[CH:15]=1)=[O:27]

Participants

3

Reactant 2

HCID 783704-Chlorobutyryl chlorideHCID 19001487HCID 19001487, compound

Product 1

HCID 19001459HCID 19001459, compoundYield 91%

Procedure

Using an analogous procedure to that described in Example 5, 6-amino-4-(3'-chloro-4'-fluoroanilino)-7-fluoroquinazoline was reacted with 4-chlorobutyryl chloride to give 6-(4-chlorobutyramido)-4-(3'-chloro-4'-fluoroanilino)-7-fluoroquinazoline hydrochloride as a solid in 91% yield;

Sources & evidence

ORD record
ord-cf8025aa3e164134bd71a81169ff4917
Source dataset
uspto-grants-1995_12
Patent number
US05475001

Reaction notes

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