Ethanol → HCID 19001543, compound

HRID 2259634Notes

Reaction equation

C(O[C:4]([NH:6][C:7]1[CH:12]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:10]=[CH:9][C:8]=1[NH:17][C:18]1[CH:23]=[C:22]([C:24]([F:27])([F:26])[F:25])[CH:21]=[CH:20][C:19]=1OC)=[O:5])C.[Na].[OH2:31].[CH2:32](O)C>>[CH3:32][O:31][C:19]1[CH:20]=[CH:21][C:22]([C:24]([F:26])([F:25])[F:27])=[CH:23][C:18]=1[N:17]1[C:8]2[CH:9]=[CH:10][C:11]([C:13]([F:16])([F:14])[F:15])=[CH:12][C:7]=2[NH:6][C:4]1=[O:5]

Participants

Reactant 4

HCID 702Ethanol

HCID 962Water

HCID 5360545Sodium

HCID 19001545HCID 19001545, compound

Product 1

HCID 19001543HCID 19001543, compound

Conditions

Temperature: 70 °C

Procedure

To an ice cooled suspension of N-(2-ethoxycarbonylamino-4-trifluoromethylphenyl)-2-methoxy-5-trifluoromethylaniline (140 mmol, 59 g) in 200 ml absolute ethanol is added sodium (174 mmol, 4 g) and the mixture is stirred at 70° C. for four hours. When the reaction is completed the reaction mixture is poured into water which is acidified and the title compound is collected by filtration as white crystals, M.p. 226° C.

Workup

filtrationthe title compound is collected by filtration as white crystals, M.p. 226° C.

Sources & evidence

ORD record: ord-d6a9e0aa9e09418d81f5451b4ebf3320
Source dataset: uspto-grants-1995_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05475015

Reaction notes

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