Nitric Acid → HCID 10912371, compound

HRID 2259644Notes

Reaction equation

HRID 2259644 reaction equation
[O:1]=[C:2]1[O:6][CH:5]([C:7]2[S:8][C:9]3[CH:15]=[CH:14][CH:13]=[CH:12][C:10]=3[N:11]=2)[CH2:4][CH2:3]1.[N+:16]([O-])([OH:18])=[O:17]>S(=O)(=O)(O)O>[N+:16]([C:14]1[CH:13]=[CH:12][C:10]2[N:11]=[C:7]([CH:5]3[CH2:4][CH2:3][C:2](=[O:1])[O:6]3)[S:8][C:9]=2[CH:15]=1)([O-:18])=[O:17]

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 19001533HCID 19001533, compound

Product 1

HCID 10912371HCID 10912371, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

504 g of the 2-(5-oxotetrahydrofuran-2-yl)-benzothiazole obtained in the Preparation Example 6 was dissolved in 2,000 ml of concentrated sulfuric acid. 188 ml of concentrated nitric acid was added dropwise to the solution at -5° to 0° C. and the mixture was stirred under the same conditions for 30 min. After stirring at 0° C. for additional 2 h, the reaction mixture was poured into about 30 l of ice/water. The precipitates thus formed were recovered by filtration, washed with water and then with ethanol and dried to give 488 g of the titled compound.

Workup

  1. stirringAfter stirring at 0° C. for additional 2 h
  2. customThe precipitates thus
  3. customformed
  4. filtrationwere recovered by filtration
  5. washwashed with water
  6. dry with materialwith ethanol and dried

Sources & evidence

ORD record
ord-1681a97019aa499d9414e906ed213282
Source dataset
uspto-grants-1995_12
Patent number
US05475014

Reaction notes

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