Nitric Acid → HCID 10912371, compound

Participants

Reaction Steps

504 g of the 2-(5-oxotetrahydrofuran-2-yl)-benzothiazole obtained in the Preparation Example 6 was dissolved in 2,000 ml of concentrated sulfuric acid. 188 ml of concentrated nitric acid was added dropwise to the solution at -5° to 0° C. and the mixture was stirred under the same conditions for 30 min. After stirring at 0° C. for additional 2 h, the reaction mixture was poured into about 30 l of ice/water. The precipitates thus formed were recovered by filtration, washed with water and then with ethanol and dried to give 488 g of the titled compound.

Provenance & Evidence