Hydrochloric Acid → HCID 19001522, compound

Participants

Reaction Steps

106 g of the ethyl N-(6-nitrobenzothiazol-2-yl)isonipecotate obtained in the Preparation Example 10 was dissolved in 300 ml of ethanol. 150 ml of 5M sodium hydroxide aqueous solution was added to the solution and the mixture was heated for 3 h. The reaction mixture was poured into dilute hydrochloric acid and precipitates thus formed were recovered by filtration, washed with water and then with ether, and dried to give 96 g of the titled compound.

Provenance & Evidence