Hydrochloric Acid → HCID 19001522, compound

HRID 2259646Notes

Reaction equation

HRID 2259646 reaction equation
[N+:1]([C:4]1[CH:23]=[CH:22][C:7]2[N:8]=[C:9]([N:11]3[CH2:21][CH2:20][CH:14]([C:15]([O:17]CC)=[O:16])[CH2:13][CH2:12]3)[S:10][C:6]=2[CH:5]=1)([O-:3])=[O:2].[OH-].[Na+].Cl>C(O)C>[N+:1]([C:4]1[CH:23]=[CH:22][C:7]2[N:8]=[C:9]([N:11]3[CH2:12][CH2:13][CH:14]([C:15]([OH:17])=[O:16])[CH2:20][CH2:21]3)[S:10][C:6]=2[CH:5]=1)([O-:3])=[O:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 19001530HCID 19001530, compound

Product 1

HCID 19001522HCID 19001522, compoundYield 98.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

106 g of the ethyl N-(6-nitrobenzothiazol-2-yl)isonipecotate obtained in the Preparation Example 10 was dissolved in 300 ml of ethanol. 150 ml of 5M sodium hydroxide aqueous solution was added to the solution and the mixture was heated for 3 h. The reaction mixture was poured into dilute hydrochloric acid and precipitates thus formed were recovered by filtration, washed with water and then with ether, and dried to give 96 g of the titled compound.

Workup

  1. temperaturethe mixture was heated for 3 h
  2. customprecipitates thus
  3. customformed
  4. filtrationwere recovered by filtration
  5. washwashed with water
  6. dry with materialwith ether, and dried

Sources & evidence

ORD record
ord-0ecb384a301244e4baa86bec04687094
Source dataset
uspto-grants-1995_12
Patent number
US05475014

Reaction notes

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