Ammonia → HCID 15342518, compound

HRID 2259653Notes

Reaction equation

HRID 2259653 reaction equation
[NH3:1].[OH:2][CH:3]1[O:7][CH:6]([C:8]2[S:9][C:10]3[CH:16]=[C:15]([N:17]4[CH2:21][CH:20]([CH2:22][O:23][CH3:24])[O:19][C:18]4=[O:25])[CH:14]=[CH:13][C:11]=3[N:12]=2)[CH2:5][CH2:4]1>>[OH:7][C@H:6]([C:8]1[S:9][C:10]2[CH:16]=[C:15]([N:17]3[CH2:21][C@H:20]([CH2:22][O:23][CH3:24])[O:19][C:18]3=[O:25])[CH:14]=[CH:13][C:11]=2[N:12]=1)[CH2:5][CH2:4][C:3](=[O:2])[NH2:1]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 15342529HCID 15342529, compound

Product 1

HCID 15342518HCID 15342518, compound

Procedure

50 ml of liquid ammonia was put in a sealed tube at -78° C. and 2.9 g of 3-[2-(5-hydroxytetrahydrofuran-2-yl)benzothiazol-6-yl]-5-methoxymethyl-2-oxazolidinone was added thereto. After sealing followed by stirring at room temperature for 3 h, ammonia was slowly evaporated. Acetone was added to the residue and the precipitated crystals were separated by filtration and dried to give 2.6 g of the titled compound.

Workup

  1. customammonia was slowly evaporated
  2. additionAcetone was added to the residue
  3. customthe precipitated crystals were separated by filtration
  4. customdried

Sources & evidence

ORD record
ord-2c23618b9d1548e0ba0f230323fe2ea5
Source dataset
uspto-grants-1995_12
Patent number
US05475014

Reaction notes

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