2-Chloro-5-nitroanisole → HCID 10825354, compound

HRID 2259687Notes

Reaction equation

HRID 2259687 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([S-:7])=[CH:3][CH:2]=1.[K+].Cl[C:10]1[CH:15]=[CH:14][C:13]([N+:16]([O-:18])=[O:17])=[CH:12][C:11]=1[O:19][CH3:20]>CN(C)C=O>[N+:16]([C:13]1[CH:14]=[CH:15][C:10]([S:7][C:4]2[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=2)=[C:11]([O:19][CH3:20])[CH:12]=1)([O-:18])=[O:17]

Participants

4

Reactant 2

HCID 705192-Chloro-5-nitroanisoleHCID 23708194HCID 23708194, compound

Product 1

HCID 10825354HCID 10825354, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of potassium 4-pyridinethiolate (20.00 g, 134 mmol) and 2-chloro-5-nitroanisole (20.91 g, 112 mmol) in dimethylformamide (80 mL) was stirred at room temperature for 24 hours. The reaction mixture was poured into ice water and a brown solid was collected by filtration. The solid was stirred with 3N HCl (400 mL) for 30 minutes, and the solution filtered. The filtrate was basified with ammonium hydroxide with cooling in an ice bath. Filtration of the basic solution yielded the title anisole as an orange solid (26.23 g, 90%); mp 133°-135° C. 1H-NMR (300 MHz, d6-DMSO): 3.95 (s, 3H, OCH3) 7.24 (dd, 2H, J=4.6, 1.7 Hz, aromatic) 7.53 (d, 1H, J=8.3 Hz, aromatic) 7.88 (dd, 2H, J=8.3, 2.3 Hz, aromatic) 8.48 (dd, 2H, J=4.7, 1.3 Hz, aromatic). MS (CI, CH4): 263 (M+1). Analysis for C12H10N2O3S: Calculated: C, 54.95; H, 3.84; N, 10.68. Found: C, 54.81; H, 3.92; N, 10.70.

Workup

  1. filtrationa brown solid was collected by filtration
  2. filtrationthe solution filtered
  3. temperaturewith cooling in an ice bath
  4. filtrationFiltration of the basic solution

Sources & evidence

ORD record
ord-808487b6206d433e8c3cf7556b035d38
Source dataset
uspto-grants-1995_12
Patent number
US05474999

Reaction notes

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