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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 225969Generated: November 2, 2026

Morpholine → (3EZ,5R)-1-(biphenyl-4-ylcarbonyl)-5-(3-morpholin-4-yl-3-oxopropyl) pyrrolidin-3-one O-methyloxime

https://huagongshe.com/reaction/225969

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMorpholineHCID 8083—
Reactant3-[(2R,4EZ)-1-(biphenyl-4-ylcarbonyl)-4-(methoxyimino)pyrrolidin-2-yl]propanoic acidHCID 131727528—
Product(3EZ,5R)-1-(biphenyl-4-ylcarbonyl)-5-(3-morpholin-4-yl-3-oxopropyl) pyrrolidin-3-one O-methyloximeHCID 13172753197%

Reaction Steps

The same method as employed in the preparation of Example 7, but starting from 3-[(2R,4EZ)-1-(biphenyl-4-ylcarbonyl)-4-(methoxyimino)pyrrolidin-2-yl]propanoic acid (Intermediate 8) and morpholine, gave the title compound. Yield: 97%. HPLC purity: 96%

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07557136B2
Source datasetuspto-grants-2009_07
ORD IDord-a82922b5dc5b415db84e450fa3a5436c
Source noteuspto-grants-2009_07