反应详情

14.52 g of 2-(1,3-benzodioxol-5-yl)-2-propanol was dissolved in 200 ml of benzene. A catalytic amount of p-toluenesulfonic acid monohydrate was added to the solution and the mixture was heated under reflux in a short-neck Kjeldahl flask provided with a Dean-Stark reflux condenser for 2.5 h. The reaction mixture was washed with a saturated aqueous sodium hydrogencarbonate solution and then with a saturated aqueous common salt solution and dried over anhydrous magnesium sulfate. After filtration, the filtrate was concentrated to obtain 14.33 g of the intended compound in the form of an oil.

1. temperaturethe mixture was heated
2. temperatureunder reflux in a short-neck Kjeldahl flask
3. customprovided with a Dean-Stark
4. temperaturereflux condenser for 2.5 h
5. washThe reaction mixture was washed with a saturated aqueous sodium hydrogencarbonate solution
6. dry with materialwith a saturated aqueous common salt solution and dried over anhydrous magnesium sulfate
7. filtrationAfter filtration
8. concentrationthe filtrate was concentrated