Thioglycolic Acid → HCID 54468475, compound

HRID 2259762Notes

Reaction equation

HRID 2259762 reaction equation
[CH:1]([C:5]1[CH:13]=[CH:12][C:8]2[O:9][CH2:10][O:11][C:7]=2[CH:6]=1)=[CH:2][CH2:3][CH3:4].[SH:14][CH2:15][C:16]([OH:18])=[O:17]>C(OCC)(=O)C>[O:9]1[C:8]2[CH:12]=[CH:13][C:5]([CH2:1][CH:2]([S:14][CH2:15][C:16]([OH:18])=[O:17])[CH2:3][CH3:4])=[CH:6][C:7]=2[O:11][CH2:10]1

Participants

4

Reactant 2

HCID 1133Thioglycolic AcidHCID 544428065-(But-1-en-1-yl)-2H-1,3-benzodioxole

Product 1

HCID 54468475HCID 54468475, compoundYield 53.7%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

2.2 g of 5-(1-butenyl)-1,3-benzodioxole and 5.4 g of mercaptoacetic acid were heated at 60° C. for 3 h. The reaction mixture was diluted with ethyl acetate, washed with water and an aqueous common salt solution and dried over magnesium sulfate. The solvent was distilled off and the product was separated according to silica gel column chromatography (chloroform) to obtain 1.8 g of the intended compound in the form of a colorless oil.

Workup

  1. washwashed with water
  2. dry with materialan aqueous common salt solution and dried over magnesium sulfate
  3. distillationThe solvent was distilled off
  4. customthe product was separated

Sources & evidence

ORD record
ord-e2850d001c3a48cda78d64cb25d2798a
Source dataset
uspto-grants-1995_12
Patent number
US05475024

Reaction notes

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