Hydrochloric Acid → HCID 86065127, compound

HRID 225983Notes

Reaction equation

HRID 225983 reaction equation
[Na+].[F:2][C:3]([F:16])([F:15])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:10][S:11]([O-:14])(=[O:13])=[O:12].Cl>CO>[F:16][C:3]([F:2])([F:15])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:10][S:11]([OH:14])(=[O:13])=[O:12]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 87451107HCID 87451107, compound

Product 1

HCID 86065127HCID 86065127, compoundYield 100.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
-20 °C

Procedure

(2-Trifluoromethylphenyl)methanesulfonic acid sodium salt (22.2 g, 84 mmol) was suspended in MeOH (950 mL) and cooled to −20° C. At that temp with continued cooling HCl (g) was bubbled through the mixture for 5 min. The resulting white suspension was stirred at room temperature for 1.5 h, then cooled in an ice-bath. The resulting suspension was filtered and the collected solid allowed to air-dry overnight to afford (2-trifluoromethylphenyl)methanesulfonic acid (20.3 g, ˜100%), a white solid, which was used without further purification

Workup

  1. customwas bubbled through the mixture for 5 min
  2. temperaturecooled in an ice-bath
  3. filtrationThe resulting suspension was filtered
  4. customto air-dry overnight

Sources & evidence

ORD record
ord-05b8f58bd65249279a4481aa15abdc0f
Source dataset
uspto-grants-2009_07
Patent number
US07557135B2

Reaction notes

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