2-Chloro-5-trichloromethylpyridine → 2-Chloro-5-(chloromethyl)pyridine

HRID 2259921Notes

Reaction equation

HRID 2259921 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](Cl)(Cl)[Cl:9])=[CH:4][N:3]=1>[Zn]>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][Cl:9])=[CH:4][N:3]=1

Participants

3

Reactant 1

HCID 502932-Chloro-5-trichloromethylpyridine3×

Product 1

HCID 1554792-Chloro-5-(chloromethyl)pyridine

Reagents, catalysts & solvents 1

HCID 23994ZincCatalyst

Procedure

The method according to claim 1, wherein 2-chloro-5-trichloromethylpyridine is reduced at a reaction temperature of from -20° C. to +100° C. with from 2 to 15 equivalents of the proton donor and from 2 to 15 equivalents of zinc, relative to 1 mol of 2-chloro-5-trichloromethylpyridine and from 0.5 to 50 parts by weight of the solvent, relative to 1 mol of 2-chloro-5-trichloromethylpyridine, to obtain 2-chloro-5-chloromethylpyridine.

Sources & evidence

ORD record
ord-49b40a89e2b7492eb5459bfe2ca97c83
Source dataset
uspto-grants-1995_12
Patent number
US05475112

Reaction notes

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