Hydrochloric Acid → HCID 19002341, compound

HRID 2260020Notes

Reaction equation

HRID 2260020 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[C:13](=[O:20])[C:12]=2[C:21](OCC)=[O:22])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].Cl.[NH:27]1[CH2:32][CH2:31][O:30][CH2:29][CH2:28]1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[C:13](=[O:20])[C:12]=2[C:21]([N:27]2[CH2:32][CH2:31][O:30][CH2:29][CH2:28]2)=[O:22])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 8083MorpholineHCID 19002379HCID 19002379, compound

Product 1

HCID 19002341HCID 19002341, compoundYield 98%

Procedure

The indenone obtained in Example 108 (0.9 g) is heated with morpholine (10 ml) for 1 hour. The reaction mixture is poured into a solution of dilute hydrochloric acid and extracted with ethyl acetate, washed with water and concentrated. The product is obtained with a yield of 98% (m.p.=71.5°; compound no. 109).

Workup

  1. extractionextracted with ethyl acetate
  2. washwashed with water
  3. concentrationconcentrated
  4. customThe product is obtained with a yield of 98% (m.p.=71.5°; compound no. 109)

Sources & evidence

ORD record
ord-5775ed1e4d1142a7a4a882f435e1ae64
Source dataset
uspto-grants-1995_12
Patent number
US05475132

Reaction notes

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