Thionyl Chloride → HCID 19002376, compound

HRID 2260026Notes

Reaction equation

HRID 2260026 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[N:19]=[C:18]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH:17]=[CH:16][C:12]=2[C:13](O)=[O:14])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].S(Cl)([Cl:28])=O>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[N:19]=[C:18]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH:17]=[CH:16][C:12]=2[C:13]([Cl:28])=[O:14])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 19002335HCID 19002335, compound

Product 1

HCID 19002376HCID 19002376, compoundYield 100%

Procedure

A mixture of 2-(3,4-dimethoxyphenyl)-6-phenylnicotinic acid (compound no. 303; 1.8 g; 0.0054 mole) and thionyl chloride (20 ml) is heated to boiling point under reflux for 1 h. The medium is concentrated under reduced pressure. A yellow syrup (1.9 g; yield=100%) is obtained.

Workup

  1. temperatureis heated
  2. temperatureunder reflux for 1 h
  3. concentrationThe medium is concentrated under reduced pressure
  4. customA yellow syrup (1.9 g; yield=100%) is obtained

Sources & evidence

ORD record
ord-151025e7a4f542dbbee2a6f4eb05bcfa
Source dataset
uspto-grants-1995_12
Patent number
US05475132

Reaction notes

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