1H-Pyrazol-3-amine, 5-methyl- → HCID 178458053, compound

HRID 2260042Notes

Reaction equation

HRID 2260042 reaction equation
[NH2:1][C:2]1[CH:6]=[C:5]([CH3:7])[NH:4][N:3]=1.[ClH:8].[C:9](=[NH:15])(OCC)[CH2:10][CH3:11]>C(#N)C>[ClH:8].[CH3:7][C:5]1[NH:4][N:3]=[C:2]([NH:1][C:9](=[NH:15])[CH2:10][CH3:11])[CH:6]=1

Participants

4

Reactant 2

HCID 931461H-Pyrazol-3-amine, 5-methyl-HCID 13000588Ethyl propanecarboximidate hydrochloride

Product 1

HCID 178458053HCID 178458053, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A 13.8 g portion of 3-amino-5-methyl-1H-pyrazole was dissolved in 52 ml of acetonitrile, and 22.0 g of ethyl propionimidate hydrochloride was added to the above solution with cooling on an ice bath. The resulting mixture was stirred for 1 hour at the same temperature and then overnight at room temperature.

Workup

  1. temperaturewith cooling on an ice bath
  2. customovernight
  3. customat room temperature

Sources & evidence

ORD record
ord-a04b8a2956f34528bf2a98b8cd87546e
Source dataset
uspto-grants-1995_12
Patent number
US05475114

Reaction notes

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