HCID 178440298, compound → HCID 178440299, compound

HRID 2260045Notes

Reaction equation

HRID 2260045 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[N:5]([N:7]=[C:8]([CH2:47][CH2:48][CH3:49])[C:9]=2[CH2:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[C:23]3[N:27](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[N:26]=[N:25][N:24]=3)=[CH:13][CH:12]=2)[N:6]=1>C(OCC)(=O)C>[CH3:1][C:2]1[NH:3][C:4]2[N:5]([N:7]=[C:8]([CH2:47][CH2:48][CH3:49])[C:9]=2[CH2:10][C:11]2[CH:12]=[CH:13][C:14]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[C:23]3[NH:24][N:25]=[N:26][N:27]=3)=[CH:15][CH:16]=2)[N:6]=1

Participants

3

Reactant 1

HCID 178440298HCID 178440298, compound2×

Product 1

HCID 178440299HCID 178440299, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A 183 mg portion of 2-methyl-6-propyl-7-[[2'-(N-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-pyrazolo[1,5-b][1,2,4]triazole (compound 1c) was treated in the same manner as described in Example 12, the resulting residue was dissolved in ethyl acetate with heating and then the solution was cooled to collect the thus formed precipitate by filtration, thereby giving 85 mg of 2-methyl-6-propyl-7-[[2'-(tetrazol-5-yl)biphenyl-4-yl]methyl]-1 H-pyrazolo[1,5-b][1,2,4]triazole in the form of colorless amorphous solid.

Workup

  1. temperaturewith heating
  2. temperaturethe solution was cooled
  3. customto collect the thus formed precipitate
  4. filtrationby filtration

Sources & evidence

ORD record
ord-4340d29a268c4706b2f2851066f2b021
Source dataset
uspto-grants-1995_12
Patent number
US05475114

Reaction notes

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