Glycidol → 3-(Tetradecylamino)propane-1,2-diol

HRID 2260082Notes

Reaction equation

HRID 2260082 reaction equation
[CH2:1]([NH2:15])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14].[CH2:16]1[O:18][CH:17]1[CH2:19][OH:20]>>[OH:18][CH:17]([CH2:19][OH:20])[CH2:16][NH:15][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14]

Participants

3

Reactant 2

HCID 11164GlycidolHCID 16217Tetradecylamine

Product 1

HCID 189993733-(Tetradecylamino)propane-1,2-diol

Procedure

Tetradecylamine (28.80 g, 0.13 mole) was heated to 85° C. Glycidol (10.00 g, 0.13 mole) was added dropwise. The reaction solution was heated under nitrogen for 3 hours and then was stirred overnight at room temperature. A white solid was obtained (crude yield=38.45 g). The solid was recrystalized from hot hexane (yield=12.2 g).

Workup

  1. temperatureThe reaction solution was heated under nitrogen for 3 hours
  2. customA white solid was obtained (crude yield=38.45 g)
  3. customThe solid was recrystalized from hot hexane (yield=12.2 g)

Sources & evidence

ORD record
ord-947894ba4c404dd990ed27846b5688c3
Source dataset
uspto-grants-1995_12
Patent number
US05476671

Reaction notes

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