Hydrochloric Acid → HCID 86749155, compound

HRID 2260096Notes

Reaction equation

HRID 2260096 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9]N)=[CH:4][CH:3]=1.C[N:12](C1C=CC=CN=1)C.[CH3:20][O:21][C:22]1[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][C:23]=1[C:24](Cl)=[O:25].Cl>N1C=CC=CC=1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][C:30]2[C:22]([O:21][CH3:20])=[C:23]([CH:27]=[C:28]([Cl:31])[CH:29]=2)[C:24]([NH2:12])=[O:25])=[CH:6][CH:7]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 4653p-FluorophenethylamineHCID 218852-DimethylaminopyridineHCID 123841765-Chloro-2-methoxybenzoyl chloride

Product 1

HCID 86749155HCID 86749155, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

1.39 g (10.0 mmol) of 4-fluoro-β-phenylethylamine are dissolved in 40 ml of pyridine, treated with a spatula tipful of dimethylaminopyridine and with a solution of 2.15 g (10.5 mmol) of 2-methoxy-5-chlorobenzoyl chloride. The reaction mixture is poured into cold dilute hydrochloric acid, and the precipitated product is filtered off with suction and dried. 4-Fluoro-β-phenylethyl-(2-methoxy-5-chlorobenzamide) is obtained as colorless crystals of melting point 85° C. The benzamide thus obtained is introduced into cold chlorosulfonic acid. After reaction is complete, the reaction mixture is poured onto ice, and the precipitate is filtered off with suction (melting point of the sulfonyl chloride: 118° C.) and dissolved in acetone. This solution is treated with excess, concentrated aqueous ammonia and, after the exothermic reaction has subsided, concentrated to a third of the original volume. The 2-methoxy-5-chloro-N-[5-(1-sulfonylamino-2-fluorophenyl)ethyl]benzamide forms colorless crystals which melt at 203° C. Heating of 2-methoxy-5-chloro-N-[5-(1-sulfonylamino-2-fluorophenyl)ethyl]benzamide in excess morpholine under reflux for three hours yields 2-methoxy-5-chloro-N-[5-(1-sulfonylamino-2-(4-morpholino)phenyl)ethyl]benzamide, which is isolated by column chromatography (silica gel 60, heptane/ethyl acetate gradient of 2:1 to 4:1). The product melts at 236° C.

Workup

  1. filtrationthe precipitated product is filtered off with suction
  2. customdried

Sources & evidence

ORD record
ord-4dff5fdab8084b6aa79fda592cd4de8d
Source dataset
uspto-grants-1995_12
Patent number
US05476850

Reaction notes

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