Potassium Hydroxide → HCID 18999823, compound

HRID 2260118Notes

Reaction equation

HRID 2260118 reaction equation
[C:1]([CH2:6][N:7]1[C:11]2=[CH:12][C:13]3[N:14]=[C:15]([C:20]4[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[C:22]([F:28])[CH:21]=4)[CH:16]=[N:17][C:18]=3[CH:19]=[C:10]2[CH:9]=[N:8]1)([O:3]CC)=[O:2].[OH-].[K+]>CO>[C:1]([CH2:6][N:7]1[C:11]2=[CH:12][C:13]3[N:14]=[C:15]([C:20]4[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[C:22]([F:28])[CH:21]=4)[CH:16]=[N:17][C:18]=3[CH:19]=[C:10]2[CH:9]=[N:8]1)([OH:3])=[O:2]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 18999871HCID 18999871, compound

Product 1

HCID 18999823HCID 18999823, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1-carboethoxymethyl-7-(3-fluoro-4-methoxyphenyl)-1H-pyrazolo[3,4-g]quinoxaline (0.3 g) is added to a solution of KOH (0.22 g) in 15 ml of methanol. The mixture is stirred at room temperature for 11/2 hours then heated at 60° C. for 2 hours. The mixture is concentrated in vacuo and the residue is stirred in 20 ml of 0.5N aqueous HCI for 1/2 hour then the solid is filtered, washed with water and ether and air dried to obtain 1-carboxymethyl-7-(3-fluoro-4-methoxyphenyl)-1H-pyrazolo[3,4-g]quinoxaline (m.p. >260° C.).

Workup

  1. temperaturethen heated at 60° C. for 2 hours
  2. concentrationThe mixture is concentrated in vacuo
  3. stirringthe residue is stirred in 20 ml of 0.5N aqueous HCI for 1/2 hour
  4. filtrationthe solid is filtered
  5. washwashed with water and ether and air
  6. customdried

Sources & evidence

ORD record
ord-2275ca99865e405fa6dfd7e73d33500c
Source dataset
uspto-grants-1995_12
Patent number
US05476851

Reaction notes

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