Potassium Hydroxide → HCID 18999823, compound

Participants

Reaction Steps

1-carboethoxymethyl-7-(3-fluoro-4-methoxyphenyl)-1H-pyrazolo[3,4-g]quinoxaline (0.3 g) is added to a solution of KOH (0.22 g) in 15 ml of methanol. The mixture is stirred at room temperature for 11/2 hours then heated at 60° C. for 2 hours. The mixture is concentrated in vacuo and the residue is stirred in 20 ml of 0.5N aqueous HCI for 1/2 hour then the solid is filtered, washed with water and ether and air dried to obtain 1-carboxymethyl-7-(3-fluoro-4-methoxyphenyl)-1H-pyrazolo[3,4-g]quinoxaline (m.p. >260° C.).

Provenance & Evidence