Oxalyl chloride → 4,4,4-Trifluorobutanoyl chloride

HRID 2260122Notes

Reaction equation

HRID 2260122 reaction equation
[F:1][C:2]([F:9])([F:8])[CH2:3][CH2:4][C:5](O)=[O:6].C(Cl)(=O)C([Cl:13])=O>C1C=CC=CC=1>[F:1][C:2]([F:9])([F:8])[CH2:3][CH2:4][C:5]([Cl:13])=[O:6]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 27770854,4,4-Trifluorobutanoic acid

Product 1

HCID 151044744,4,4-Trifluorobutanoyl chloride

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

4,4,4-Trifluorobutyric acid (5.8 g, 0.041 mole) was dissolved in benzene (30 ml). Oxalyl chloride (6.2 g, 0.049 mole) was added and the reaction stirred for 20 hrs. The benzene and excess oxalyl chloride was removed by distillation to give the title compound.

Workup

  1. customThe benzene and excess oxalyl chloride was removed by distillation

Sources & evidence

ORD record
ord-98662f13159444a9995ab68452fbc37c
Source dataset
uspto-grants-1995_12
Patent number
US05476859

Reaction notes

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