Hydrogen Bromide → HCID 136375558, compound

HRID 2260301Notes

Reaction equation

HRID 2260301 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]([C:14]2[N:15]=[C:16]([C:20]([C:22]3[N:23]([CH3:40])[CH:24]=[C:25]([C:27]4[CH:32]=[C:31]([N+:33]([O-:35])=[O:34])[C:30]([O:36]C)=[C:29]([O:38]C)[CH:28]=4)[N:26]=3)=[O:21])[N:17]([CH3:19])[CH:18]=2)[CH:6]=[C:7]([N+:11]([O-:13])=[O:12])[C:8]=1[O:9]C.[BrH:41]>>[BrH:41].[OH:2][C:3]1[CH:4]=[C:5]([C:14]2[N:15]=[C:16]([C:20]([C:22]3[N:23]([CH3:40])[CH:24]=[C:25]([C:27]4[CH:32]=[C:31]([N+:33]([O-:35])=[O:34])[C:30]([OH:36])=[C:29]([OH:38])[CH:28]=4)[N:26]=3)=[O:21])[N:17]([CH3:19])[CH:18]=2)[CH:6]=[C:7]([N+:11]([O-:13])=[O:12])[C:8]=1[OH:9]

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 86749158HCID 86749158, compound

Product 1

HCID 136375558HCID 136375558, compound

Procedure

5.0 g of 3,4-dimethoxy-5-nitrophenyl(1-methylimidazol-2-yl)ketone are treated with 50 ml of hydrobromic acid (48%), whereupon the mixture is stirred under reflux temperature for 2 hours. After cooling the separated precipitate is filtered under suction, washed with ice-water and recrystallized from ethanol. There is obtained 3,4-dihydroxy-5-nitrophenyl(1-methyl-imidazol-2-yl)ketone hydrobromide in the form of yellow crystals of decomposition point>240°.

Workup

  1. temperatureunder reflux temperature for 2 hours
  2. temperatureAfter cooling the separated precipitate
  3. filtrationis filtered under suction
  4. washwashed with ice-water
  5. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-65311b242c3641489aa2bdf3414d4750
Source dataset
uspto-grants-1995_12
Patent number
US05476875

Reaction notes

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