Iodoethane → 2-Amino-1-ethylpyridinium iodide

HRID 2260338Notes

Reaction equation

HRID 2260338 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[I:8][CH2:9][CH3:10]>>[I-:8].[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N+:3]=1[CH2:9][CH3:10]

Participants

3

Reactant 2

HCID 6340IodoethaneHCID 104392-Aminopyridine

Product 1

HCID 162382042-Amino-1-ethylpyridinium iodide

Procedure

28.2 g of 2-aminopyridine and 60.8 g of iodoethane were fed into a 1 l three-necked flask provided with a reflux condenser and they were heated under reflux for 2 hours. The reaction liquid was stirred at room temperature for additional 1 hour. Crystals thus formed were suction-filtered and washed with ethyl acetate (50 ml×2). The filtration residue was dried at room temperature under reduced pressure for 3 hours to obtain the intended compound.

Workup

  1. customprovided with a reflux condenser
  2. temperaturethey were heated
  3. temperatureunder reflux for 2 hours
  4. customThe reaction liquid
  5. customCrystals thus formed
  6. filtrationwere suction-filtered
  7. washwashed with ethyl acetate (50 ml×2)
  8. customThe filtration residue was dried at room temperature under reduced pressure for 3 hours
  9. customto obtain the intended compound

Sources & evidence

ORD record
ord-8d1f0522a70742a0bc3f644e26c4912d
Source dataset
uspto-grants-1995_12
Patent number
US05476945

Reaction notes

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