Methyl p-toluenesulfonate → 2-Amino-1-methylpyrimidinium p-toluenesulfonate

HRID 2260339Notes

Reaction equation

HRID 2260339 reaction equation
[NH2:1][C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[C:8]1([CH3:19])[CH:13]=[CH:12][C:11]([S:14]([O:17]C)(=[O:16])=[O:15])=[CH:10][CH:9]=1>CC(C)=O>[C:8]1([CH3:19])[CH:9]=[CH:10][C:11]([S:14]([O-:17])(=[O:15])=[O:16])=[CH:12][CH:13]=1.[NH2:1][C:2]1[N:7]=[CH:6][CH:5]=[CH:4][N+:3]=1[CH3:8]

Participants

4

Reactant 2

HCID 6645Methyl p-toluenesulfonateHCID 79782-Aminopyrimidine

Product 1

HCID 199621922-Amino-1-methylpyrimidinium p-toluenesulfonate

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Conditions

Temperature
120 °C

Procedure

1.8 g of 2-aminopyrimidine and 5.6 g of methyl p-toluenesulfonate were fed into a 200 ml three-necked flask and the mixture was stirred under heating on an oil bath at 120° C. for 3 hours. The reaction mixture was cooled to 60° C., to which 100 ml of acetone was added and the resultant mixture was stirred at room temperature for 1 hour. The crystals thus formed were suction-filtered, washed with acetone and dried at room temperature under reduced pressure.

Workup

  1. additionwas added
  2. customThe crystals thus formed
  3. filtrationwere suction-filtered
  4. washwashed with acetone
  5. customdried at room temperature under reduced pressure

Sources & evidence

ORD record
ord-b4b8839600a74db6a4cdaf41299b47f3
Source dataset
uspto-grants-1995_12
Patent number
US05476945

Reaction notes

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