4-Chlorobenzenesulfonyl chloride → HCID 18999489, compound

HRID 2260403Notes

Reaction equation

HRID 2260403 reaction equation
[NH2:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]1[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:11][CH:10]=1.C(N(CC)CC)C.[Cl:28][C:29]1[CH:34]=[CH:33][C:32]([S:35](Cl)(=[O:37])=[O:36])=[CH:31][CH:30]=1>ClCCl.CCOCC>[Cl:28][C:29]1[CH:34]=[CH:33][C:32]([S:35]([NH:1][CH:2]2[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]2[CH2:8][C:9]2[CH:10]=[CH:11][C:12]([CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:13][CH:14]=2)(=[O:37])=[O:36])=[CH:31][CH:30]=1

Participants

6

Reactant 3

HCID 73984-Chlorobenzenesulfonyl chlorideHCID 8471TriethylamineHCID 18999537HCID 18999537, compound

Product 1

HCID 18999489HCID 18999489, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

Obtained by operating as in example 1c from 6.1 g (22 mmoles) of ethyl 4-[(2-aminocyclohexyl)methyl]benzeneacetate, 2.7 g (26.5 mmoles) of triethylamine in 150 ml of dichloromethane and 4.6 g (22 mmoles) of 4-chlorobenzenesulfonyl chloride in 50 ml of ether. The colorless oil obtained (yield=quantitative) is used without any other purification.

Workup

  1. customObtained
  2. customThe colorless oil obtained
  3. custom(yield=quantitative)
  4. customis used without any other purification

Sources & evidence

ORD record
ord-5e9fe3084bba49158947ee6456bab16b
Source dataset
uspto-grants-1995_12
Patent number
US05476846

Reaction notes

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