HCID 22857993, compound → HCID 22858006, compound

HRID 2260441Notes

Reaction equation

HRID 2260441 reaction equation
[CH3:1][C:2]([C:5]1[CH:10]=[C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])[CH:8]=[CH:7][C:6]=1[S:15][C@H:16]1[CH2:20][CH2:19][CH2:18][C@H:17]1[OH:21])([CH3:4])[CH3:3]>C(Cl)(Cl)Cl>[CH3:4][C:2]([C:5]1[CH:10]=[C:9]([C:11]([CH3:12])([CH3:13])[CH3:14])[CH:8]=[CH:7][C:6]=1[S:15][C@@H:16]1[CH2:20][CH2:19][CH2:18][C@H:17]1[OH:21])([CH3:1])[CH3:3]

Participants

3

Reactant 1

HCID 22857993HCID 22857993, compound

Product 1

HCID 22858006HCID 22858006, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The title compound was prepared by the method described in Example 83, except that the title product of Example 90, Compound B, was substituted for the title product of Example 82, Compound B. The structure was supported by NMR, Ir, optical rotation (CHCl3, 25° C.; 589 nm -10.5°±2.69°; 365 nm -63.4°±18.1°), chiral HPLC (chiralpak-AD) major 98.84%, minor 0.68% (product of Example 90, Compound A) and elemental analysis.

Workup

  1. customThe title compound was prepared by the method

Sources & evidence

ORD record
ord-b5331ff9086649188a9c7814ca82c8d7
Source dataset
uspto-grants-1995_12
Patent number
US05476944

Reaction notes

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