Dimethylformamide → HCID 18998366, compound

HRID 2260491Notes

Reaction equation

HRID 2260491 reaction equation
Cl[C:2]1[CH:7]=[C:6]([CH3:8])[N:5]2[N:9]=[C:10]([N:12]3[CH2:17][CH2:16][O:15][CH2:14][CH2:13]3)[N:11]=[C:4]2[N:3]=1.CN(C)C=O.[CH:23]([NH:26][CH:27]([CH3:29])[CH3:28])([CH3:25])[CH3:24]>>[CH:23]([N:26]([CH:27]([CH3:29])[CH3:28])[C:2]1[CH:7]=[C:6]([CH3:8])[N:5]2[N:9]=[C:10]([N:12]3[CH2:17][CH2:16][O:15][CH2:14][CH2:13]3)[N:11]=[C:4]2[N:3]=1)([CH3:25])[CH3:24]

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 7912DiisopropylamineHCID 18998415HCID 18998415, compound

Product 1

HCID 18998366HCID 18998366, compound

Procedure

To a solution of 2.54 g (0.01 mole) of 5-chloro-7-methyl-2-morpholino-1,2,4-triazolo[1,5-a]pyrimidine in 10 ml of dimethylformamide 2.02 g (0.02 mole≈2.8 ml) of diisopropylamine are added, and the reaction mixture is boiled for 24 hours under stirring. The solution thus obtained is evaporated to dryness in vacuo and the residue is recrystallized from 20 ml of water.

Workup

  1. customThe solution thus obtained
  2. customis evaporated to dryness in vacuo
  3. customthe residue is recrystallized from 20 ml of water

Sources & evidence

ORD record
ord-68af06e0f96f441daecf16c8282673e7
Source dataset
uspto-grants-1995_12
Patent number
US05478825

Reaction notes

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